E^2
Pronounced, "E Squared", E^2 is a unquie sprite comic created by a freind of mine. Characters of which you've probably seen elsewhere on the site.
Subtle, political, hidden, long winded, come to mind.

Megatokyo
A long running english manga with more than five books out and a large following. One of the few webcomic artists living off of his work.

Penny Arcade
Probably the most well known webcomic on the web. Lamppons anyone and anything dealing with the game industry or what ever catches their eye.

VG Cats
A great drawn comic about two cats and the games they love. Some of the best game satire I have ever seen. Too bad it updates so slowly...

8Bit
The most popular sprite comic on the web. 8-bit theatre defined the archtypes used in most webcomics today. Also the inspiration for me to start Twobit. It has finsihed after it's long run, but they have several other on going comics to always have something new.

Somthing Positive
A great, well written, and uplifting comic. Okay, maybe not uplifting, but a great on going story.

Bob & George
One of the oldest sprite comics on the internet, Bob and George is a great ever evolving storyline dealing with the Mega Man series of games. Unfortunately it has come to an end.